Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications.
Identifieur interne : 008E82 ( Main/Exploration ); précédent : 008E81; suivant : 008E83Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications.
Auteurs : D. Kyelem [Burkina Faso] ; S. Sanou ; B. Boatin ; J. Medlock ; S. Coulibaly ; D H MolyneuxSource :
- Annals of tropical medicine and parasitology [ 0003-4983 ] ; 2003.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Antihelminthiques antinématodes (usage thérapeutique), Burkina, Enfant, Enfant d'âge préscolaire, Femelle, Filarioses (traitement médicamenteux), Humains, Ivermectine (usage thérapeutique), Maladies endémiques, Mansonella, Mansonellose (traitement médicamenteux), Mâle, Nourrisson, Population rurale, Répartition par âge, Sujet âgé, Wuchereria bancrofti.
- MESH :
- traitement médicamenteux : Filarioses, Mansonellose.
- usage thérapeutique : Antihelminthiques antinématodes, Ivermectine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Burkina, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Maladies endémiques, Mansonella, Mâle, Nourrisson, Population rurale, Répartition par âge, Sujet âgé, Wuchereria bancrofti.
- Wicri :
- geographic : Burkina Faso.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Distribution, Aged, Animals, Antinematodal Agents (therapeutic use), Burkina Faso, Child, Child, Preschool, Endemic Diseases, Female, Filariasis (drug therapy), Humans, Infant, Ivermectin (therapeutic use), Male, Mansonella, Mansonelliasis (drug therapy), Middle Aged, Rural Population, Wuchereria bancrofti.
- MESH :
- chemical , therapeutic use : Antinematodal Agents, Ivermectin.
- geographic : Burkina Faso.
- drug therapy : Filariasis, Mansonelliasis.
- Adolescent, Adult, Age Distribution, Aged, Animals, Child, Child, Preschool, Endemic Diseases, Female, Humans, Infant, Male, Mansonella, Middle Aged, Rural Population, Wuchereria bancrofti.
Abstract
Parasitological and clinical surveys were used to determine the long-term impact of ivermectin on the prevalence of Wuchereria bancrofti and Mansonella perstans filarial infections, when the drug was given under community-directed-treatment strategies for onchocerciasis control. The study was undertaken in 11 communities in south-western Burkina Faso. Six of the villages investigated had been treated with ivermectin at least once a year for five of 6 years, with a mean coverage of approximately 65% in each round. The other five, adjacent villages, which were matched with the ivermectin-treated communities by size, ethnicity and social and economic activities, had never been treated because they were not endemic for onchocerciasis. Each subject was checked by the microscopical examination of a smear of 'night' blood, by measurement of the level of circulating antigens from adult W. bancrofti, and by clinical examination for hydrocele (if male) and lymphoedema. The prevalences of lymphoedema and hydrocele in the treated villages were similar to those in the untreated. The prevalences and intensities of W. bancrofti and M. perstans microfilaraemia were, however, significantly lower in the ivermectin-treated communities. The implications of this study are discussed in relation to the old Onchocerciasis Control Programme (OCP) and to the ongoing African Programme for Onchocerciasis (APOC), where extensive and sustained ivermectin distribution is planned through community-based treatment programmes. As with onchocerciasis in Africa, the success of annual treatments to control lymphatic filariasis will depend not only on the number of regular rounds of treatment given but on adequate coverages being achieved in each round. Wherever ivermectin is being distributed alone, for onchocerciasis control, its impact on other filarial infections, notably W. bancrofti, should be evaluated routinely. Any opportunity to add donated albendazole to such distributions should be taken, both to limit the transmission of W. bancrofti and for the wider public-health benefits.
DOI: 10.1179/000349803225002462
PubMed: 14754495
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 004083
- to stream PubMed, to step Curation: 004083
- to stream PubMed, to step Checkpoint: 004083
- to stream Ncbi, to step Merge: 001812
- to stream Ncbi, to step Curation: 001812
- to stream Ncbi, to step Checkpoint: 001812
- to stream Main, to step Merge: 009174
- to stream Main, to step Curation: 008E82
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications.</title><author><name sortKey="Kyelem, D" sort="Kyelem, D" uniqKey="Kyelem D" first="D" last="Kyelem">D. Kyelem</name><affiliation wicri:level="1"><nlm:affiliation>Lymphatic Filariasis Programme, Ministry of Health, 03 BP 7009, Ouagadougou, Burkina Faso. dominiquekyelem@yahoo.fr</nlm:affiliation><country xml:lang="fr">Burkina Faso</country><wicri:regionArea>Lymphatic Filariasis Programme, Ministry of Health, 03 BP 7009, Ouagadougou</wicri:regionArea><wicri:noRegion>Ouagadougou</wicri:noRegion></affiliation></author><author><name sortKey="Sanou, S" sort="Sanou, S" uniqKey="Sanou S" first="S" last="Sanou">S. Sanou</name></author><author><name sortKey="Boatin, B" sort="Boatin, B" uniqKey="Boatin B" first="B" last="Boatin">B. Boatin</name></author><author><name sortKey="Medlock, J" sort="Medlock, J" uniqKey="Medlock J" first="J" last="Medlock">J. Medlock</name></author><author><name sortKey="Coulibaly, S" sort="Coulibaly, S" uniqKey="Coulibaly S" first="S" last="Coulibaly">S. Coulibaly</name></author><author><name sortKey="Molyneux, D H" sort="Molyneux, D H" uniqKey="Molyneux D" first="D H" last="Molyneux">D H Molyneux</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14754495</idno><idno type="pmid">14754495</idno><idno type="doi">10.1179/000349803225002462</idno><idno type="wicri:Area/PubMed/Corpus">004083</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004083</idno><idno type="wicri:Area/PubMed/Curation">004083</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004083</idno><idno type="wicri:Area/PubMed/Checkpoint">004083</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004083</idno><idno type="wicri:Area/Ncbi/Merge">001812</idno><idno type="wicri:Area/Ncbi/Curation">001812</idno><idno type="wicri:Area/Ncbi/Checkpoint">001812</idno><idno type="wicri:doubleKey">0003-4983:2003:Kyelem D:impact:of:long</idno><idno type="wicri:Area/Main/Merge">009174</idno><idno type="wicri:Area/Main/Curation">008E82</idno><idno type="wicri:Area/Main/Exploration">008E82</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications.</title><author><name sortKey="Kyelem, D" sort="Kyelem, D" uniqKey="Kyelem D" first="D" last="Kyelem">D. Kyelem</name><affiliation wicri:level="1"><nlm:affiliation>Lymphatic Filariasis Programme, Ministry of Health, 03 BP 7009, Ouagadougou, Burkina Faso. dominiquekyelem@yahoo.fr</nlm:affiliation><country xml:lang="fr">Burkina Faso</country><wicri:regionArea>Lymphatic Filariasis Programme, Ministry of Health, 03 BP 7009, Ouagadougou</wicri:regionArea><wicri:noRegion>Ouagadougou</wicri:noRegion></affiliation></author><author><name sortKey="Sanou, S" sort="Sanou, S" uniqKey="Sanou S" first="S" last="Sanou">S. Sanou</name></author><author><name sortKey="Boatin, B" sort="Boatin, B" uniqKey="Boatin B" first="B" last="Boatin">B. Boatin</name></author><author><name sortKey="Medlock, J" sort="Medlock, J" uniqKey="Medlock J" first="J" last="Medlock">J. Medlock</name></author><author><name sortKey="Coulibaly, S" sort="Coulibaly, S" uniqKey="Coulibaly S" first="S" last="Coulibaly">S. Coulibaly</name></author><author><name sortKey="Molyneux, D H" sort="Molyneux, D H" uniqKey="Molyneux D" first="D H" last="Molyneux">D H Molyneux</name></author></analytic><series><title level="j">Annals of tropical medicine and parasitology</title><idno type="ISSN">0003-4983</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Animals</term><term>Antinematodal Agents (therapeutic use)</term><term>Burkina Faso</term><term>Child</term><term>Child, Preschool</term><term>Endemic Diseases</term><term>Female</term><term>Filariasis (drug therapy)</term><term>Humans</term><term>Infant</term><term>Ivermectin (therapeutic use)</term><term>Male</term><term>Mansonella</term><term>Mansonelliasis (drug therapy)</term><term>Middle Aged</term><term>Rural Population</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Antihelminthiques antinématodes (usage thérapeutique)</term><term>Burkina</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Filarioses (traitement médicamenteux)</term><term>Humains</term><term>Ivermectine (usage thérapeutique)</term><term>Maladies endémiques</term><term>Mansonella</term><term>Mansonellose (traitement médicamenteux)</term><term>Mâle</term><term>Nourrisson</term><term>Population rurale</term><term>Répartition par âge</term><term>Sujet âgé</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antinematodal Agents</term><term>Ivermectin</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Burkina Faso</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Filariasis</term><term>Mansonelliasis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filarioses</term><term>Mansonellose</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihelminthiques antinématodes</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Distribution</term><term>Aged</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Endemic Diseases</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Mansonella</term><term>Middle Aged</term><term>Rural Population</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Burkina</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Maladies endémiques</term><term>Mansonella</term><term>Mâle</term><term>Nourrisson</term><term>Population rurale</term><term>Répartition par âge</term><term>Sujet âgé</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Burkina Faso</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parasitological and clinical surveys were used to determine the long-term impact of ivermectin on the prevalence of Wuchereria bancrofti and Mansonella perstans filarial infections, when the drug was given under community-directed-treatment strategies for onchocerciasis control. The study was undertaken in 11 communities in south-western Burkina Faso. Six of the villages investigated had been treated with ivermectin at least once a year for five of 6 years, with a mean coverage of approximately 65% in each round. The other five, adjacent villages, which were matched with the ivermectin-treated communities by size, ethnicity and social and economic activities, had never been treated because they were not endemic for onchocerciasis. Each subject was checked by the microscopical examination of a smear of 'night' blood, by measurement of the level of circulating antigens from adult W. bancrofti, and by clinical examination for hydrocele (if male) and lymphoedema. The prevalences of lymphoedema and hydrocele in the treated villages were similar to those in the untreated. The prevalences and intensities of W. bancrofti and M. perstans microfilaraemia were, however, significantly lower in the ivermectin-treated communities. The implications of this study are discussed in relation to the old Onchocerciasis Control Programme (OCP) and to the ongoing African Programme for Onchocerciasis (APOC), where extensive and sustained ivermectin distribution is planned through community-based treatment programmes. As with onchocerciasis in Africa, the success of annual treatments to control lymphatic filariasis will depend not only on the number of regular rounds of treatment given but on adequate coverages being achieved in each round. Wherever ivermectin is being distributed alone, for onchocerciasis control, its impact on other filarial infections, notably W. bancrofti, should be evaluated routinely. Any opportunity to add donated albendazole to such distributions should be taken, both to limit the transmission of W. bancrofti and for the wider public-health benefits.</div></front></TEI><affiliations><list><country><li>Burkina Faso</li></country></list><tree><noCountry><name sortKey="Boatin, B" sort="Boatin, B" uniqKey="Boatin B" first="B" last="Boatin">B. Boatin</name><name sortKey="Coulibaly, S" sort="Coulibaly, S" uniqKey="Coulibaly S" first="S" last="Coulibaly">S. Coulibaly</name><name sortKey="Medlock, J" sort="Medlock, J" uniqKey="Medlock J" first="J" last="Medlock">J. Medlock</name><name sortKey="Molyneux, D H" sort="Molyneux, D H" uniqKey="Molyneux D" first="D H" last="Molyneux">D H Molyneux</name><name sortKey="Sanou, S" sort="Sanou, S" uniqKey="Sanou S" first="S" last="Sanou">S. Sanou</name></noCountry><country name="Burkina Faso"><noRegion><name sortKey="Kyelem, D" sort="Kyelem, D" uniqKey="Kyelem D" first="D" last="Kyelem">D. Kyelem</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008E82 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008E82 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:14754495
|texte= Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:14754495" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |